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To avoid an increased risk of rashthe recommended initial dose and subsequent dose escalations for LAMICTAL should not be exceededsee BOXED WARNING

Gradual transient increasesinlamotrigine plasmalevels(approximate 2-fold increase)occurred duringtheweek of inactivehormone preparationpill-freeweekfor womennotalso takinga drug that increased the clearance of lamotriginecarbamazepinephenytoinphenobarbitalprimidoneor other drugs such as rifampin and the protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir that induce lamotrigine glucuronidationsee DRUG INTERACTIONSThe increase in lamotrigine plasma levels will be greater if the dose of LAMICTAL is increased in the few days before or during the pill-free weekIncreases in lamotrigine plasma levels could result in dose-dependent adverse reactions.

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