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Cilostazol reversibly impaired fertility of female mice but not in other animal speciessee section 5.3The clinical significance is unknown.

The pharmacokinetics of cilostazol and its metabolites were similar in subjects with mild hepatic disease as compared to healthy subjects.

The effect of CYP3A4 and CYP2C19 inducerssuch as carbamazepinephenytoinrifampicin and StJohn’s worton cilostazol pharmacokinetics has not been evaluatedThe antiplatelet effect may theoretically be altered and should be carefully monitored when cilostazol is co-administered with CYP3A4 and CYP2C19 inducers.

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