54 55 breastfeeding in women taking olanzapine is advised against due to the fact that olanzapine is secreted in breast milk with one study finding that the exposure to the infant in mg per kg of body weight, that is is about 1.
Appropriate clinical monitoring is recommendedincluding fasting blood lipid testing at the beginning ofand periodically duringtreatment.
Patients are at risk for severe sedationincluding comaor delirium after each injection and must be observed for at least 3 hours in registered facility with ready access to emergency response services.
Not approved for dementia-related psychosisbecause of increased risk of cardiovascular or infection-related mortality.
Bipolar I DisorderManic or Mixed EpisodesOlanzapine as Adjunct to Lithium or ValproateIn a study of patients who were already tolerating either lithium or valproate as monotherapydiscontinuation rates due to adverse reactions were 11for the combination of oral olanzapine with lithium or valproate compared to 2for patients who remained on lithium or valproate monotherapyDiscontinuations with the combination of oral olanzapine and lithium or valproate that occurred in more than 1 patient weresomnolence3weight gain1and peripheral edema1
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chlorpheniramine; phenylephrine moderate olanzapine exhibits anticholinergic effects that may be clinically significant.