Acalabrutinib is a cyp3a4 substrate; diltiazem is a moderate cyp3a4 inhibitor.

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Heart rhythm problemsIn people with certain types of heart rhythm problemssick sinus syndromesecondand third-degree atrio-ventricular blockwho do not have pacemakersdiltiazem may cause abnormally slow heart ratesPeople with certain types of heart rhythm problems should not take diltiazemIf you have a heart rhythm problemyour doctor should closely monitor your condition while you are taking diltiazemTalk to your doctor if you have any concerns.

You should not stop using diltiazem suddenlyStopping suddenly may make your condition worse.

Diltiazem belongs to a class of drugs called calcium channel blockersA class of drugs refers to medications that work similarlyThey have a similar chemical structure and are often used to treat similar conditions.

Get emergency medical help if you have signs of an allergic reaction to diltiazemhivesdifficult breathingswelling of your facelipstongueor throat.

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